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In another embodiment, the present invention is directed toward a modified TetR(B) protein comprising a plurality of amino acid substitutions at positions selected from the group consisting of positions 59, 70, 71, 91, 95, 96, 98, 99, 100, 101, 103, 110, 114, 127, 157, 158, 159, 160, 178, 188, 192, 194, 196, 200, and 205 of the TetR(B) protein as depicted in SEQ ID NO: 36, wherein said modified TetR(B) betnesol glaxosmithkline binds a TetR(B) operator sequence with greater affinity in the presence of tetracycline than in the absence of tetracycline.

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If betnesol rezeptpflichtig subject did not successfully complete this first dosing period, he was discontinued from the study.

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